EPCLUSA VS. VOSEVI
Here we look at how Epclusa and Vosevi are alike and different.
Epclusa contains the drugs velpatasvir and sofosbuvir in one tablet. Vosevi also contains velpatasvir and sofosbuvir in one tablet, but it also contains a third drug: voxilaprevir.
Epclusa and Vosevi are both FDA-approved to treat any of the six hepatitis C genotypes in adults without cirrhosis or with compensated cirrhosis. Epclusa is also approved to treat adults with decompensated cirrhosis.
Epclusa is approved to treat people who haven’t tried any hepatitis C regimen in the past, or who have tried treatments that didn’t work for them.
Vosevi, on the other hand, is approved to be used as a treatment for people who have tried only certain hepatitis C drugs and not had success with them. For instance, Vosevi is approved to treat:
- people with any genotype who have tried a certain type of antiviral called an NS5A inhibitor in the past
- people with genotypes 1a or 3 who have previously tried treatment that included sofosbuvir
If you’ve had hepatitis C treatment in the past, your doctor can tell you if this past medication use makes you eligible for treatment with Vosevi.
Forms and administration
Epclusa and Vosevi are both taken as one pill once daily. Epclusa can be taken with or without food, while Vosevi should be taken with food.
Both medications are taken for 12 weeks.
Side effects and risks
Epclusa and Vosevi are similar medications and cause many of the same side effects. Examples of these side effects are listed below.
More common side effects
More common side effects that can occur with both Epclusa and Vosevi include:
- trouble sleeping
In addition to these side effects, people taking Vosevi may also experience diarrhea.
Less common side effects that can occur with both Epclusa and Vosevi include mild rash.
Serious side effects
Serious side effects that can occur with both Epclusa and Vosevi include:
- reactivation of the hepatitis B virus*
- serious allergic reactions, including angioedema (severe swelling)
* Epclusa and Vosevi both have a boxed warning from the FDA for hepatitis B reactivation. A boxed warning is the strongest warning the FDA requires. It alerts doctors and patients about drug effects that may be dangerous.
Epclusa and Vosevi have been directly compared in studies.
In one clinical study, Vosevi cured hepatitis C in more people than Epclusa. The researchers reported that 90 percent of people who took Epclusa for 12 weeks were cured of hepatitis C compared to 98 percent of people who took Vosevi.
Epclusa and Vosevi are both brand-name drugs. There are currently no generic forms of either drug. Brand-name medications usually cost more than generics.
Epclusa and Vosevi generally cost about the same. The actual cost you pay for either drug will depend on your insurance plan.