HARVONI VS. ZEPATIER

Here we look at how Harvoni and Zepatier are alike and different.

Harvoni contains the drugs ledipasvir and sofosbuvir in one pill. Zepatier also contains two drugs in one pill: elbasvir and grazoprevir.

Uses

Harvoni and Zepatier are both FDA-approved to treat hepatitis C virus in adults with genotypes 1 or 4. Harvoni is also approved for treating genotypes 5 and 6 in adults, and genotypes 1, 4, 5, or 6 in children ages 12 or older or who weigh at least 77 pounds. Zepatier isn’t approved for use in children.

Harvoni is approved to treat hepatitis C virus in adults with decompensated cirrhosis or who’ve had a liver transplant. With these conditions, your doctor will likely prescribe ribavirin with Harvoni.

Zepatier isn’t approved for use in people with moderate or severe liver disease, decompensated cirrhosis, or after a liver transplant.

Zepatier is FDA-approved for use in people with genotypes 1 and 4 who have a condition called polymorphism. With this condition, a person has certain genetic variations (mutations) that make the virus resistant to certain medications. When a virus is resistant, it’s difficult to treat with certain drugs.

Your doctor will perform a blood test see if you have one of these variations. If you do, you may need to take ribavirin with Zepatier.

Drug forms and administration

Harvoni and Zepatier both come as a single tablet that’s taken once daily. Each can be taken with or without food.

Harvoni treatment lasts for 8, 12, or 24 weeks. Zepatier treatment lasts for 12 or 16 weeks. The duration of treatment your doctor prescribes will be based on your genotype, liver function, and history of past hepatitis C treatments.

Side effects and risks

Harvoni and Zepatier are similar medications and their effects on the body are alike. Therefore, they cause many of the same side effects.

Below are some examples of their side effects.

More common side effects

These lists contain examples of more common side effects that can occur with Harvoni, with Zepatier, or with both drugs (when taken individually).

  • Can occur with Harvoni:
    • feeling weak
    • insomnia (trouble sleeping)
    • cough
    • feeling irritable
  • Can occur with Zepatier:
    • stomach pain
    • elevated liver enzyme (alanine aminotransferase)
  • Can occur with both Harvoni and Zepatier:
    • fatigue
    • headache
    • irritability
    • diarrhea

Serious side effects

Serious side effects that can occur with both Harvoni and Zepatier include:

  • hepatitis B reactivation (when a previous infection becomes active again), which can lead to severe liver damage, liver failure, or death (see “Boxed warnings” below)
  • serious allergic reaction, with symptoms that can include trouble breathing and angioedema (swelling under your skin, typically in your eyelids, lips, hands, or feet)

Boxed warnings

Harvoni and Zepatier both have boxed warnings from the FDA. A boxed warning is the strongest warning the FDA requires.

The warning describes a risk of hepatitis B reactivation after starting treatment with either drug. Hepatitis B reactivation can lead to serious liver damage, liver failure, or death.

Your doctor will test you for hepatitis B before you start taking Harvoni or Zepatier. If you test positive for hepatitis B, you may need to take medication to treat it.

Effectiveness

Harvoni and Zepatier haven’t been compared in clinical studies, but both are effective for treating hepatitis C.

According to treatment guidelines, both Harvoni and Zepatier are recommended as first-choice options to treat hepatitis C in adults with genotypes 1 and 4. Harvoni is also a first-choice option for treating genotypes 5 and 6, but Zepatier isn’t.

Guideline recommendations for Harvoni and Zepatier also differ in the following conditions:

  • Children ages 12 and older or who weigh 77 pounds or more: Harvoni is a first-choice option for treating these children who have genotypes 1, 4, 5, and 6. Zepatier isn’t recommended for use in children.
  • Severe kidney disease: Zepatier is recommended as a first-choice option for people with this condition, while Harvoni isn’t.
  • Decompensated cirrhosis: In people with decompensated cirrhosis, Harvoni is recommended as a first-choice option. Zepatier isn’t recommended for people with this condition.
  • Liver or kidney transplant: Harvoni is a first-choice option for treating hepatitis C in people who’ve had a liver or kidney transplant. Zepatier isn’t recommended for people with these conditions.

Costs

Harvoni and Zepatier are both brand-name medications. Brand-name medications usually cost more than generics.

Note: A generic version of Harvoni was released in early 2019. The manufacturer estimates the cost for a course of the drug is approximately $24,000. This price is considerably less than the price of the brand-name version.

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"This pharmacy is one of the best. Pharmacist has lots of knowledge and staff takes time to explain in detail. They do other half of what doctors should do. Also, no waiting like big name pharmacy. I highly recommend this pharmacy. They also deliver and ship to anywhere in USA."
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Drug Mart Pharmacy
5.0
Based on 163 reviews
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Chanice Dorsey
Chanice Dorsey
02:45 12 Mar 20
The staff at Drug Mart are truly an extension of my family. Vik offered me one of the greatest opportunities while in... nursing school, as a graduate, and as a working professional. He continues to encourage young adults to pursue their dreams and provides them with opportunities to be impactful within the community. You can’t get any better than this.read more
langston hannah
langston hannah
12:02 07 Mar 20
I am very pleased with the service that I receive from the pharmacy. The people who serve you are very helpful and... friendly and assist you in any way that they can. The pharmacist are well informed with your prescription needs, if there's a problem with anything you need they will do their best to resolve any issue you have. I recommend everyone to check them out and get their prescriptions filled at Drug Mart. I will always be a customer of Drug Mart because they are so good at what they do.read more
Yolanda Mesa
Yolanda Mesa
15:11 05 Mar 20
The best pharmacy I ever went. Staff is very polite and friendly. Very fast and they also deliver. One time I totally... forget about a medication and they went to my house.read more
tracey evans
tracey evans
16:32 03 Mar 20
Drug Mart is my family, I’ve been with them since day 1. I moved away for a few years to another state, I’ve been... back i NJ. a little over 5 years and I’m still a happy customer. They’re very friendly, knowledgeable and very helpful and understanding, prices are better then most..read more
Cassandra Hemby
Cassandra Hemby
21:33 28 Feb 20
I so appreciate the dear people @Drug Mart! I am recovering from cancer and one day while in Chemotherapy I was told I... would need a certain cream right away, but I wouldn't be able to pick it up that day.however there is this very courteous and sweet young lady named Michele that assured me it would be delivered to me in at my daughter's home in Woodbridge, NJ, because that is where I go after having treatment.The kind of caring and compassion received there have made the staff endearing to me and has restored my faith in customer service again.read more
Denise Eady
Denise Eady
20:38 24 Feb 20
I love this place. Best pharmacy around!!!. I have been using this pharmacy since it opened. Whenever I walk in,... everyone is very cordial and always pleasant and with a smile, and they always greet me by nmy name. Vic and the other Pharmacists are very knowledgeable, and the staff takes the time to explain any new medications in detail. If you are not able to pick up your prescriptions, they do HOME delivery which is great. I transferred from Walgreens pharmacy and I am so glad I did!!!read more
Jay Bhatt
Jay Bhatt
21:05 22 Feb 20
The quality of service provided by the pharmacist and the staff is excellent! I wouldn't go to any other pharmacy. They... truly care.read more
Cindy Hall
Cindy Hall
15:21 20 Feb 20
I never have to wait. This is the best pharmacy I ever went to. I highly recommend them to everyone!
Maisha Bryant
Maisha Bryant
00:32 20 Feb 20
I have known Vik and his family since they opened. They have bright back what it means to have a home town family... operated pharmacy. He remembers you, that you have had a baby etc. He is compassionate and always goes above and beyond. He trains his staff to pursue their own dreams. Some have gone on to school. My prayer is that God gives him a long healthy life and that his business continues to prosper. Oh and BTW if you move he does mail order so he can continue to be your pharmacist no need to switch!read more
Sharel E. Gordon-Love
Sharel E. Gordon-Love
19:46 19 Feb 20
My family has been with Drug Mart since they first open and we’ve received top notch service every single time. Vic... and the staff are very friendly, and we are greeted with a smileread more
Tammy Nichols
Tammy Nichols
23:23 18 Feb 20
I used to get my prescriptions at Cvs. But when Drug Mart open close to my house i figured I give then a try and have... not looked back. The staff is always kind, helpful, and considerate. LOVE THIS PLACE.❤read more
Yolanda Parker
Yolanda Parker
20:50 17 Feb 20
I enjoyed the customer service I experience when I go into this store the friendly atmosphere the warm welcome you get... upon entering and exitingread more
Mike Webb
Mike Webb
16:48 06 Feb 20
Great being able to pick up my meds at this pharmacy. They are the best!
Janet Bynum
Janet Bynum
18:21 28 Jan 20
Leaving his experience I had with Drug Mart it's coming there getting my medication and then delivering it to me very... happy who had Drug Mart in my life far as my medications is concerned I don't have to call for refills they deliver them to me I've been the drug mart play my medications concern about 7 years or more appreciate the people they appreciate me I'm happy with Drug Mart this is my the best pharmacist that I know thank youread more
james hunter
james hunter
21:25 24 Jan 20
Always ready to help! Any way possible thank you for all your years of service!
Michelle Reyes
Michelle Reyes
21:03 24 Jan 20
Awesome staff always willing to help out 🙂
cindy ortega
cindy ortega
20:41 24 Jan 20
I love this pharmacy. Everyone makes you feel like your family. Any issues with prescription they try to resolve it... asap. I recommend this pharmacy to everyone.read more
jacqueline wells
jacqueline wells
19:33 31 Dec 19
Drug mart has the most pleasant employees and the service is swift I can't say enough good things about this pharmacy... Thanks for your years of dedication and service in our communityread more
Chris Hanington
Chris Hanington
13:47 18 Jul 19
These people take great care of THEIR people. Impressive!
R Turner
R Turner
21:57 01 Jun 19
I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started... but their service is still top notch. Thanks again for all your help!read more
John Aleksandrowicz
John Aleksandrowicz
22:21 14 Apr 19
Great pharmacy with great customer service. Vik is great. He obviously cares about people and understands the needs of... each. Thank you!read more
Karen T
Karen T
18:54 06 Jan 19
This pharmacy is the best! I left Walgreens and very glad I did. They take the time to explain my medicines and know me... by name. I recommended them to all my family and friends.read more
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