ZEPATIER

grazoprevir/elbasvir, or GZR/EBR

Treatment of patients with chronic hepatitis C virus (HCV).
FDA approved for HIV/HCV co-infection.

GENOTYPE 

Zepatier tab

STANDARD DOSE

One tablet once daily with or without food. Each tablet contains 100 mg of grazoprevir and 50 mg of elbasvir. Ribavirin may be added in patients with certain baseline NS5A polymorphisms (mutations that may make the Zepatier less effective).

Zepatier can be used in severe renal impairment, including in patients on hemodialysis. NS3/4A protease inhibitors, such as grazoprevir, are contraindicated in patients with moderate or severe liver impairment (Child-Pugh B/C), which is also called decompensated cirrhosis. Using Zepatier in decompensated cirrhosis may cause significantly higher amounts of grazoprevir in the blood and may increase ALT (liver enzyme).

Take your missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose.

BLACK BOX WARNING

Before starting treatment with any direct-acting antiviral (DAA), including Zepatier, patients should take a blood test to check for hepatitis B (HBV) infection. HBV infection could get worse or reactivate during or after DAA treatment, potentially leading to serious liver problems, including liver failure or death. Patients with current or past HBV infection should be monitored during HCV DAA treatment, and some may need to take HBV treatment.

MANUFACTURER

Merck and Co.
zepatier.com
(800) 622–4477

PHARMACY

Drug Mart Pharmacy
shopdrugmart.com
(800) 877-0337

GET STARTED – Request To Fill Your Medication

Before starting Zepatier, be sure to tell your medical provider or pharmacist about all of the medications, supplements, and herbal products you take, whether they are prescribed, over-the-counter, or illicit. It is also important to inform them of any changes as they happen during treatment. Zepatier should not be taken with HIV medications that require a booster (meaning they require another medication such as ritonavir or cobicistat to increase the drug levels in the body), such as atazanavir, darunavir, or elvitegravir. Zepatier should also not be taken with the HIV medications efavirenz or etravirine. Use with certain statins (cholesterol medicine) may cause increased risk of muscle pain (myopathy) or muscle breakdown (rhabdomyolysis). Your doctor should decide if your statin should be continued or changed during treatment with Zepatier. There are no interactions with methadone or other common medications used for opioid, alcohol, or nicotine dependency. Unlike several of the other HCV medications, Zepatier does not interact with acid reducing agents. It should not be taken with the rifamycin antimicrobials, such as rifabutin, rifampin, or rifapentine, nor should it be taken with the anticonvulsants carbamazepine, phenytoin, phenobarbital, or oxcarbazepine. It cannot be taken with St. John’s wort, and in general, herbal products should be avoided due to lack of information regarding potential for interaction.

Zepatier was an excellent medication upon its release, but it is not used much any longer as the other newer DAAs are preferred. Of particular importance: This regimen is especially effective in patients with kidney disease, including those on hemodialysis, with 99% achieving an SVR12.

Taking your Zepatier tablets exactly as your doctor prescribes is extremely important. That’s because following your treatment plan increases your chances of curing your hepatitis C (HCV). It also helps reduce your risk of long-term effects of HCV, such as cirrhosis and liver cancer.

Missing doses can interfere with how well Zepatier treats your hepatitis C. In some cases, if you miss doses, your HCV may not be cured.

So be sure to follow your doctor’s instructions and take your Zepatier tablet every day for the duration of your treatment. Using a reminder tool can be helpful in making sure you take Zepatier each day.

If you have any questions or concerns about your treatment, talk with your doctor or pharmacist. They can help resolve any issues for you and help you get the most out of your treatment.

FAQs

Our pharmacists are experts in treating hepatitis C, medication therapy and finding valuable treatment resources. We keep Zepatier in stock for the duration of your treatment so you never have to wait to receive your medication. If you have any issues with your insurance plan or coverage, we’ll find a solution so you don’t miss a dose. You can rest assured that you have picked a partner who will work with you and your doctor to achieve your treatment goals.

Drug Mart offers free prescription delivery to any location (home or office) in New Jersey, New York or Pennsylvania.

Drug Mart is licensed in New Jersey, New York and Pennsylvania. If you live in one of these States, complete the form at Get Started, and our pharmacy team will handle the rest.

Merck, the maker of Zepatier has a prescription copay assistance program. Our staff is trained to find these savings and help lower the price you pay for your prescription. In most cases, patients pay zero dollar out-of-pocket for their Zepatier prescription.

Zepatier is FDA-approved to treat hepatitis C virus in adults with genotypes 1 or 4.

Zepatier is FDA-approved for use in people with genotypes 1 and 4 who have a condition called polymorphism. With this condition, a person has certain genetic variations (mutations) that make the virus resistant to certain medications. When a virus is resistant, it’s difficult to treat with certain drugs.

Your doctor will perform a blood test see if you have one of these variations. If you do, you may need to take ribavirin with Zepatier.

Zepatier isn’t approved for use in children.

Zepatier isn’t approved for use in people with moderate or severe liver disease, decompensated cirrhosis, or after a liver transplant.

Zepatier treatment lasts for 12 or 16 weeks. The duration of treatment your doctor prescribes will be based on your genotype, liver function, and history of past hepatitis C treatments.

It doesn’t matter what time of day you choose to take Zepatier, but you should take it at about the same time each day. This helps the medication work the right way inside your body.

You may take Zepatier with or without food.

It’s important that you don’t miss or skip doses of Zepatier and that you take the full course of treatment. Missing doses or not completing the course will make Zepatier less effective against the hepatitis C virus. This could mean that your hepatitis C won’t be cured.

To help make sure you don’t miss a dose, try setting a reminder on your phone.

If you forget to take a dose at your usual time, take it as soon as you remember that day. But if you don’t remember until the following day, just take your regular dose. Never take two doses to make up for a missed dose. This could raise your risk for getting side effects.

You shouldn’t crush, split, or chew Zepatier tablets. The effect of crushing, chewing, or breaking Zepatier hasn’t been studied.

It could affect the way your body absorbs the medication. It’s not known if this would change how safe or effective the drug is.

If you have trouble swallowing Zepatier tablets whole, talk with your doctor about your options for other treatments.

Zepatier is a type of drug called a direct-acting antiviral. It contains two active drugs: grazoprevir and elbasvir. Each of these drugs works in a slightly different way to stop the hepatitis C virus from making copies of itself.

The hepatitis C virus uses certain proteins within the virus to make copies of itself. Each of the drugs in Zepatier stops a different protein from working. This means the virus can’t multiply.

Viruses that can’t make copies of themselves eventually die or are removed by your immune system. This clears up the infection and prevents further damage to your liver.

Zepatier will start working right away, but you’ll need to take the full 12 or 16-week course of treatment to cure the infection.

Your doctor will test your blood for the virus during treatment and 12 to 16 weeks after you finish treatment. If the virus is not detected in your blood after your treatment ends, you’re considered cured of hepatitis C.

Yes. Zepatier is FDA approved to be used as a treatment in HIV and HCV co-infection. Your doctor will choose the treatment plan based on your clinical situation.

Yes, your doctor will do blood tests to check for the hepatitis B virus before you start treatment.

If these tests show you have the hepatitis B virus, you may need to take medication to treat it. This is because taking Zepatier can make the hepatitis B virus become active in your body again, which can lead to liver failure and death.

It’s not known if Zepatier is safe to take during pregnancy. It hasn’t been studied in pregnant women.

If you’re pregnant or considering becoming pregnant, talk with your doctor about your treatment options.

It’s not known if Zepatier is safe to take while breastfeeding. It’s unknown if the active drugs in Zepatier pass into human breast milk.

Zepatier was highly effective in participants with compensated cirrhosis, with cure rates between 97% and 100%.

There are six different types, or strains, of hepatitis C viruses that infect people. These strains are called genotypes.

Genotypes are identified by differences in the genetic code of the viruses. Genotype 1 is the most common hepatitis C strain in the United States, but other strains are also seen in this country.

Your doctor will do a blood test to figure out which genotype you have. Your hepatitis C genotype will help your doctor choose the right medication for you.

You should avoid drinking alcohol while you’re taking Zepatier to treat hepatitis C. Drinking alcohol could cause further damage to your liver. It can also increase your risk for getting Zepatier side effects such as headaches, diarrhea, nausea, and fatigue (lack of energy).

Talk with your doctor if you’re concerned about avoiding alcohol during your Zepatier treatment.

Do not use more Zepatier than your doctor recommends.

If you think you’ve taken too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool.

If your symptoms are severe, call 911 or go to the nearest emergency room right away.

Call us at the pharmacy and we’ll be glad to answer any questions. You can reach us at (800) 877-0337.

More FAQs. Find answers to commonly asked questions at Pharmacy FAQs.

Karen T.
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"They truly care, I tell everyone to go here. I've been with them since 2008."
Yolanda P.
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"Always helpful to save money on medication and very kind."
Michael A.
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"Helpful and knowledgeable. Can't ask for better service, thank you!"
Patti E.
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"The staff at Drug Mart are exceptionally helpful. The quality of their products are top notch. I recommend Drug Mart to everyone. Am with them for life!!"
Darryl F.
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"This is the best pharmacy I have ever been to. They are caring, helpful and treat you with respect."
Anita H.
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"My daughter was able to get emergency medication after hours within half hour of making the phone call to the 800#. I can't recommend Drug Mart more highly."
Robert T.
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"I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started but their service is still top notch. Thanks again for all your help!"
David D.
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"They are most accommodating, courteous, friendly and professional pharmacist I've ever dealt with. I'm so grateful to call this pharmacy my own."
Tonia B.
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"Always very caring when asking a question about your medication they know what they're talking about and they are very knowledgeable I've been going to them for oh my goodness since they opened up wow where did time go anyway my drug store for life thank you!"
Josh P.
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"This pharmacy is one of the best. Pharmacist has lots of knowledge and staff takes time to explain in detail. They do other half of what doctors should do. Also, no waiting like big name pharmacy. I highly recommend this pharmacy. They also deliver and ship to anywhere in USA."
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Drug Mart Pharmacy
5.0
Based on 163 reviews
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Chanice Dorsey
Chanice Dorsey
02:45 12 Mar 20
The staff at Drug Mart are truly an extension of my family. Vik offered me one of the greatest opportunities while in... nursing school, as a graduate, and as a working professional. He continues to encourage young adults to pursue their dreams and provides them with opportunities to be impactful within the community. You can’t get any better than this.read more
langston hannah
langston hannah
12:02 07 Mar 20
I am very pleased with the service that I receive from the pharmacy. The people who serve you are very helpful and... friendly and assist you in any way that they can. The pharmacist are well informed with your prescription needs, if there's a problem with anything you need they will do their best to resolve any issue you have. I recommend everyone to check them out and get their prescriptions filled at Drug Mart. I will always be a customer of Drug Mart because they are so good at what they do.read more
Yolanda Mesa
Yolanda Mesa
15:11 05 Mar 20
The best pharmacy I ever went. Staff is very polite and friendly. Very fast and they also deliver. One time I totally... forget about a medication and they went to my house.read more
tracey evans
tracey evans
16:32 03 Mar 20
Drug Mart is my family, I’ve been with them since day 1. I moved away for a few years to another state, I’ve been... back i NJ. a little over 5 years and I’m still a happy customer. They’re very friendly, knowledgeable and very helpful and understanding, prices are better then most..read more
Cassandra Hemby
Cassandra Hemby
21:33 28 Feb 20
I so appreciate the dear people @Drug Mart! I am recovering from cancer and one day while in Chemotherapy I was told I... would need a certain cream right away, but I wouldn't be able to pick it up that day.however there is this very courteous and sweet young lady named Michele that assured me it would be delivered to me in at my daughter's home in Woodbridge, NJ, because that is where I go after having treatment.The kind of caring and compassion received there have made the staff endearing to me and has restored my faith in customer service again.read more
Denise Eady
Denise Eady
20:38 24 Feb 20
I love this place. Best pharmacy around!!!. I have been using this pharmacy since it opened. Whenever I walk in,... everyone is very cordial and always pleasant and with a smile, and they always greet me by nmy name. Vic and the other Pharmacists are very knowledgeable, and the staff takes the time to explain any new medications in detail. If you are not able to pick up your prescriptions, they do HOME delivery which is great. I transferred from Walgreens pharmacy and I am so glad I did!!!read more
Jay Bhatt
Jay Bhatt
21:05 22 Feb 20
The quality of service provided by the pharmacist and the staff is excellent! I wouldn't go to any other pharmacy. They... truly care.read more
Cindy Hall
Cindy Hall
15:21 20 Feb 20
I never have to wait. This is the best pharmacy I ever went to. I highly recommend them to everyone!
Maisha Bryant
Maisha Bryant
00:32 20 Feb 20
I have known Vik and his family since they opened. They have bright back what it means to have a home town family... operated pharmacy. He remembers you, that you have had a baby etc. He is compassionate and always goes above and beyond. He trains his staff to pursue their own dreams. Some have gone on to school. My prayer is that God gives him a long healthy life and that his business continues to prosper. Oh and BTW if you move he does mail order so he can continue to be your pharmacist no need to switch!read more
Sharel E. Gordon-Love
Sharel E. Gordon-Love
19:46 19 Feb 20
My family has been with Drug Mart since they first open and we’ve received top notch service every single time. Vic... and the staff are very friendly, and we are greeted with a smileread more
Tammy Nichols
Tammy Nichols
23:23 18 Feb 20
I used to get my prescriptions at Cvs. But when Drug Mart open close to my house i figured I give then a try and have... not looked back. The staff is always kind, helpful, and considerate. LOVE THIS PLACE.❤read more
Yolanda Parker
Yolanda Parker
20:50 17 Feb 20
I enjoyed the customer service I experience when I go into this store the friendly atmosphere the warm welcome you get... upon entering and exitingread more
Mike Webb
Mike Webb
16:48 06 Feb 20
Great being able to pick up my meds at this pharmacy. They are the best!
Janet Bynum
Janet Bynum
18:21 28 Jan 20
Leaving his experience I had with Drug Mart it's coming there getting my medication and then delivering it to me very... happy who had Drug Mart in my life far as my medications is concerned I don't have to call for refills they deliver them to me I've been the drug mart play my medications concern about 7 years or more appreciate the people they appreciate me I'm happy with Drug Mart this is my the best pharmacist that I know thank youread more
james hunter
james hunter
21:25 24 Jan 20
Always ready to help! Any way possible thank you for all your years of service!
Michelle Reyes
Michelle Reyes
21:03 24 Jan 20
Awesome staff always willing to help out 🙂
cindy ortega
cindy ortega
20:41 24 Jan 20
I love this pharmacy. Everyone makes you feel like your family. Any issues with prescription they try to resolve it... asap. I recommend this pharmacy to everyone.read more
jacqueline wells
jacqueline wells
19:33 31 Dec 19
Drug mart has the most pleasant employees and the service is swift I can't say enough good things about this pharmacy... Thanks for your years of dedication and service in our communityread more
Chris Hanington
Chris Hanington
13:47 18 Jul 19
These people take great care of THEIR people. Impressive!
R Turner
R Turner
21:57 01 Jun 19
I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started... but their service is still top notch. Thanks again for all your help!read more
John Aleksandrowicz
John Aleksandrowicz
22:21 14 Apr 19
Great pharmacy with great customer service. Vik is great. He obviously cares about people and understands the needs of... each. Thank you!read more
Karen T
Karen T
18:54 06 Jan 19
This pharmacy is the best! I left Walgreens and very glad I did. They take the time to explain my medicines and know me... by name. I recommended them to all my family and friends.read more
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