rilpivirine/emtricitabine/tenofovir disoproxil fumarate (RPV/FTC/TDF)
Recommended initial regimen in certain clinical situations
One tablet once daily, with a standard meal (more than 390 calories) for adults and children 12 years of age and older weighing at least 77 pounds (35 kg). Tablet contains 25 mg of the NNRTI rilpivirine plus 200 mg emtricitabine and 300 mg tenofovir DF (TDF).
Must be taken with a meal that you chew—not just nutritional drinks or protein shakes. Taking rilpivirine without food could result in a 40% decrease in drug absorption and may lead to resistance.
People taking HIV treatment for the first time must have an HIV RNA (viral load) of less than 100,000 copies/mL and a CD4 T-cell count of more than 200 cells/mm3 before starting Complera due to higher rates of virologic failure in these patients.
Take missed dose as soon as possible, unless it’s closer to the time of your next dose. Do not double up on your next dose. Complera should not be used in people with CrCl less than 50 mL/min or severe liver impairment.
➤ See the individual drugs contained in complera: Edurant and Truvada (co-formulation of Emtriva and Viread).
➤ See package insert for more complete information on potential side effects and interactions.
Gilead Sciences, Inc.
(800) GILEAD-5 (445–3235)
(800) JANSSEN (526-7736)
Moderate to severe side effects are uncommon. Insomnia, headache, and depressive disorders (depression, negative thoughts, suicidal thoughts or actions) were each reported in 2% of study participants. Cases of rash and increased liver enzymes have also been reported with regimens containing rilpivirine. There may be a small increase in serum creatinine (SCr) and decrease in estimated creatinine clearance (CrCl) associated with rilpivirine. See Truvada page for other possible effects on kidney function. Prior to initiation, people should be tested for hepatitis B (HBV) infection. Severe exacerbations of hepatitis B have been reported in people who are co-infected with hepatitis B and have discontinued the emtricitabine and/or tenofovir components. Monitor liver enzymes closely in people co-infected with hepatitis B and, if appropriate, initiation of anti-hepatitis B therapy may be warranted.
Tell your provider or pharmacist about all medications, herbals, and supplements you are taking or thinking of taking, prescribed or not, as there are other drug interactions which are not listed here. Do not take with Epivir-HBV, Hepsera, or Vemlidy (TAF), all three used for treatment of hepatitis B. Proton pump inhibitors (PPIs, heartburn or stomach acid drugs like Aciphex, Dexilant, Nexium, Prevacid, Prilosec, Protonix, etc.) can’t be taken with Complera. Antacids containing aluminum, magnesium hydroxide, or calcium carbonate can be taken at least two hours before or at least four hours after a Complera dose. Stomach acid-reducing drugs like Pepcid, Tagamet, and Zantac can be taken at least 12 hours before or at least four hours after a Complera dose. Do not take Complera with carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifampin, rifapentine, or the herb St. John’s wort (other herbals have not been studied with Complera, but consult with a pharmacist before taking any herbals or OTC supplements). Rifabutin must be taken with an extra Edurant tablet in addition to Complera. Do not take with more than one dose of the injectable steroid dexamethasone (sometimes given in the ER or hospital). Use caution if used with fluconazole, itraconazole, ketoconazole, posaconazole, and voriconazole. Use azithromycin when possible instead of the antibiotics clarithromycin, erythromycin, or telithromycin, because these drugs increase rilpivirine levels, which can increase the risk of side effects. Reduced methadone levels can occur and while dose adjustments are not necessary, it is recommended to monitor for withdrawal symptoms. Complera should also not be taken with other medications that prolong QTc interval (a heart problem) or medications with a known risk of torsades de pointes. Complera may be taken with Daklinza, Harvoni, Olysio, Sovaldi, and Zepatier. Monitor for tenofovir toxicities with Epclusa. Complera cannot be taken with Viekira Pak. Not intended to be taken with other HIV medications, unless prescribed that way. Tell your provider or pharmacist about all medications, herbals, and supplements you are taking or thinking of taking, prescribed or not, as there are other drug interactions which are not listed here.
Complera can be relatively difficult to take because of its food requirement and drug interactions. In addition, strict adherence is critical due to its relatively low barrier to the development of resistance. A newer version of Complera, Odefsey, contains tenofovir alafenamide (TAF) instead of tenofovir DF; TAF is safer on kidney and bone health. Also as a result of the TAF, Odefsey can be taken by people with more advanced kidney disease, down to a renal function (CrCL) of 30 mL/min.
Complera is the combination of three HIV medicines contained in one single tablet and taken once a day. It is comparable to Odefsey as it combines rilpivirine with emtricitabine and the original tenofovir disoproxil fumarate while Odefsey contains tenofovir alafenamide. Complera is recommended as an initial therapy in certain clinical situations for individuals with a viral load less than 100,000 copies. It could also be prescribed to those wanting to replace their current regimen and have had suppressed viral load (less than 50 copies) for at least six months. It is not recommended if the reason for replacement is due to developing resistance to other antivirals, more so those contained in Complera. You need to watch for drug-drug interactions and changes in liver and kidney functions.
Our pharmacists are experts in managing HIV/AIDS, medication therapy and finding valuable treatment resources. We always keep Complera in stock so you never have to wait to receive your medication. If you have any issues with your insurance plan or coverage, we’ll find a solution so you don’t miss a dose. You can rest assured that you have picked a partner who will work with you and your doctor to achieve your treatment goals.
Yes. Drug Mart pharmacy stocks all of the latest HIV/AIDS medications, including Complera.
Drug Mart offers free prescription delivery to any location (home or office) in New Jersey, New York or Pennsylvania.
Drug Mart is licensed in New Jersey, New York and Pennsylvania. If you live in one of these States, complete the form at Get Started, and our pharmacy team will handle the rest.
Yes. Drug Mart offers the blister pack, multi-dose medication packaging to any patient who take more than 5 medications per day. Each pack is made up of 28 individual blisters containing a person’s prescribed medication for a specific time and date. This service is completely free-of-charge.
Gilead, the maker of Complera has a prescription copay assistance program. Our staff is trained to find these savings and help lower the price you pay for your prescription. In most cases, patients pay zero dollar out-of-pocket for their Complera prescription.
Complera is a complete, 1-pill, once-a-day prescription medicine used to treat HIV-1 in adults and children who weigh at least 77 lb (35 kg) and meet certain requirements, as determined by a health care provider. It is used to treat HIV in people who have never taken HIV medicines before.
According to the U.S. Department of Health and Human Services, many patients can get to undetectable in 48 weeks, when taking their treatment as prescribed.
Yes! 100% of Medicare Advantage plans and Medicare Part D plans cover Complera. Drug coverage may vary based on plan availability. You may be able to find Medicare Advantage plan options in your area that cover Complera.
Always take Complera with food. It nust be taken with a meal that you chew—not just nutritional drinks or protein shakes.
Complera can be taken anytime of the day. However, you should try to take the medication around the same time each day.
If you miss a dose of Complera within 12 hours of the time you usually take it, take your dose with food as soon as possible. Then take your next dose at the regularly scheduled time. If you miss a dose by more than 12 hours of the time you usually take it, wait and then take the next dose at the regularly scheduled time. Do not take more than your prescribed dose to make up for a missed dose.
Tablets can be crushed and added to small amount of liquid or semi-solid food; consume immediately. It may have a bitter taste.
Do not take Complera with carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifampin, rifapentine, or the herb St. John’s wort (other herbals have not been studied with Complera, but consult with a pharmacist before taking any prescription medications, herbals or OTC supplements).
Yes, you may take a multivitamin. No interactions were found between Complera and multivitamins. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Yes. Always consult your healthcare provider.
Tenofovir may cause kidney problems. Combining it with other medications that can also affect the kidney such as ibuprofen may increase that risk. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.
There is no direct interaction between alcohol and Complera. However, there can be an indirect interaction between alcohol and adherence. Drinking alcohol occasionally with your treatment will not affect the efficacy of Complera. Drinking alcohol in moderation should not have an effect on your health or treatment. This is also dependent on not having other liver related problems like hepatitis B or C.
Common side effects of Complera include: headache, dizziness, tiredness; depressed mood, sleep problems (insomnia), strange dreams; rash; nausea, diarrhea; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
Complera can cause serious, life-threatening side effects. These include a buildup of lactic acid in the blood (lactic acidosis) and severe liver problems. Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis: Feeling very weak or tired.
Common side effects of Complera include: depression. Other side effects include: attempted suicide, suicidal ideation, arthralgia, depressed mood, dysphoria, major depressive disorder, and myalgia.
If you stop taking Complera, even for a short time, the amount of virus in your blood may increase. The virus may become harder to treat.
It is not known if Complera can harm your unborn child. Tell your doctor if you are pregnant or plan to become pregnant.
Tell your doctor if you are breastfeeding. You should not breastfeed if you are HIV-positive because of the chance of passing the HIV virus to your baby.
Call us at the pharmacy and we’ll be glad to answer any questions. You can reach us at (800) 877-0337.