EPIVIR

lamivudine (3TC)

Recommended as a component of initial regimen for most people when used in combination with doultegravir and abacavir

NRTI drug

Nucleoside “Nuke”

Epivir tablet

STANDARD DOSE

One 300 mg tablet once daily (or one 150 mg tablet twice daily), without regard to food. Dosing needs to be adjusted for adults and children who have decreased kidney function (creatinine clearance less than 50 mL/min). See package insert for guidance on dosing in the setting of kidney impairment. Must be taken in combination with another antiretroviral(s), which does not contain the medication in this drug.

According to the package insert, it is indicated for adults and children at least 3 months of age and older. Based on pediatric DHHS guidelines, it can be used as part of an empiric HIV regimen in infants of at least 32 weeks’ gestation at birth for higher risk perinatal HIV exposure. Epivir for children is dosed based on body weight. See the package insert and/or DHHS guidelines for weight-based dosing.

Take missed dose as soon as possible, unless it is closer to the time of your next dose. Do not double up on your next dose. The 150 mg tablets are scored and may be split. Based on drug properties, tablets may be crushed and added to a small amount of semi-solid food or liquid for immediate consumption. Epivir is also available as an oral solution (10mg/mL) (strawberry-banana flavor) for children and adults who are not able to swallow the tablets. Can be substituted for Emtriva.

MANUFACTURER

ViiV Healthcare
viivhealthcare.com
(877) 844-8872

PHARMACY

Drug Mart Pharmacy
shopdrugmart.com
(800) 877-0337

GET STARTED – Request To Fill Your Medication

  •    See package insert for more complete information on potential side effects and interactions.

Epivir is very well tolerated. The most common side effects with incidence greater than or equal to 15% were headache, diarrhea, nausea, malaise (general ill feeling), fatigue, nasal symptoms, diarrhea, and cough. If you have HIV and HBV, guidelines recommend treatment for both viruses. Emtriva can treat both HIV and HBV, but must be used in combination with another hepatitis B drug (such as tenofovir) to treat the hep B. If you are co-infected with HBV and HIV, you should not stop Epivir without medical supervision because it can cause your HBV to flare up and cause you to experience signs and symptoms of acute hepatitis. HBV should be closely monitored by your provider.

No significant drug interactions. Epivir may be used with hepatitis C drugs such as Daklinza, Epclusa, Harvoni, Olysio, Sovaldi, Viekira Pak, or Zepatier, depending on the other components in the HIV regimen. Avoid use of sorbitol-containing medicines with lamivudine; there are many, such as acetaminophen liquid (Tylenol liquid and others).

Epivir (lamivudine) is similar to Emtriva (emtricitabine): both treat HIV and HBV and have the same resistance profile, meaning that if your virus is resistant to one drug, it will be resistant to the other. If your HIV develops resistance to lamivudine, it doesn’t mean that your HBV is also resistant to it. Sometimes, drug resistance that the virus develops against lamivudine makes the virus reproduce at a slower rate. This drug resistance can also improve the antiviral activity of Retrovir (zidovudine) and Viread (tenofovir), and for that reason, some providers continue Epivir treatment in combination with other antiretrovirals after resistance develops. Lamivudine is also available in several combination products: Cimduo (with tenofovir DF), Combivir (with zidovudine), Epzicom (with abacavir), Trizivir (with zidovudine and abacavir), Symfi and Symfi Lo (with tenofovir DF and efavirenz), Delstrigo (with tenofovir DF and doravirine), and Triumeq (with dolutegravir and abacavir). Epivir as part of the combination tablet Combivir is recommended as an alternative NRTI combination component of an ART regimen during pregnancy. Epivir is available as generic lamivudine, which should be as effective and well tolerated as the brand name drug Epivir. Some insurers may require patients to take regimens containing generics rather than brand name drugs, including simpler co-formulated products. For example, since both zidovudine (Retrovir, AZT) and lamivudine are available in generic form, a person might have to take these two generic pills instead of the fixed-dose combination tablet Combivir. The availability of generics might also limit choices of therapy. For example, newer brand name drugs and co-formulations, such as Genvoya or Triumeq, might be restricted to patients who can’t physically tolerate generic regimens.

See package insert for more complete information on potential side effects and interactions.

Epivir, or lamivudine, is the oldest antiretroviral still in use today. It is well tolerated, very effective, and has no drug-drug interactions. It has been used in combination with other NRTIs like zidovudine (Combivir) and abacavir (Epzicom) and is a component of the single-tablet regimen Triumeq. It is used to treat individuals co-infected with HIV and HBV. It seems to work best in combination with other nukes as the backbone of a regimen. The only downside is its resistance profile. One mutation (M184V) can reduce its effectiveness.

Karen T.
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"They truly care, I tell everyone to go here. I've been with them since 2008."
Yolanda P.
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"Always helpful to save money on medication and very kind."
Michael A.
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"Helpful and knowledgeable. Can't ask for better service, thank you!"
Patti E.
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"The staff at Drug Mart are exceptionally helpful. The quality of their products are top notch. I recommend Drug Mart to everyone. Am with them for life!!"
Darryl F.
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"This is the best pharmacy I have ever been to. They are caring, helpful and treat you with respect."
Anita H.
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"My daughter was able to get emergency medication after hours within half hour of making the phone call to the 800#. I can't recommend Drug Mart more highly."
Robert T.
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"I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started but their service is still top notch. Thanks again for all your help!"
David D.
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"They are most accommodating, courteous, friendly and professional pharmacist I've ever dealt with. I'm so grateful to call this pharmacy my own."
Tonia B.
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"Always very caring when asking a question about your medication they know what they're talking about and they are very knowledgeable I've been going to them for oh my goodness since they opened up wow where did time go anyway my drug store for life thank you!"
Josh P.
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"This pharmacy is one of the best. Pharmacist has lots of knowledge and staff takes time to explain in detail. They do other half of what doctors should do. Also, no waiting like big name pharmacy. I highly recommend this pharmacy. They also deliver and ship to anywhere in USA."
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Drug Mart Pharmacy
5.0
Based on 163 reviews
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Chanice Dorsey
Chanice Dorsey
02:45 12 Mar 20
The staff at Drug Mart are truly an extension of my family. Vik offered me one of the greatest opportunities while in... nursing school, as a graduate, and as a working professional. He continues to encourage young adults to pursue their dreams and provides them with opportunities to be impactful within the community. You can’t get any better than this.read more
langston hannah
langston hannah
12:02 07 Mar 20
I am very pleased with the service that I receive from the pharmacy. The people who serve you are very helpful and... friendly and assist you in any way that they can. The pharmacist are well informed with your prescription needs, if there's a problem with anything you need they will do their best to resolve any issue you have. I recommend everyone to check them out and get their prescriptions filled at Drug Mart. I will always be a customer of Drug Mart because they are so good at what they do.read more
tracey evans
tracey evans
16:32 03 Mar 20
Drug Mart is my family, I’ve been with them since day 1. I moved away for a few years to another state, I’ve been... back i NJ. a little over 5 years and I’m still a happy customer. They’re very friendly, knowledgeable and very helpful and understanding, prices are better then most..read more
Cassandra Hemby
Cassandra Hemby
21:33 28 Feb 20
I so appreciate the dear people @Drug Mart! I am recovering from cancer and one day while in Chemotherapy I was told I... would need a certain cream right away, but I wouldn't be able to pick it up that day.however there is this very courteous and sweet young lady named Michele that assured me it would be delivered to me in at my daughter's home in Woodbridge, NJ, because that is where I go after having treatment.The kind of caring and compassion received there have made the staff endearing to me and has restored my faith in customer service again.read more
Denise Eady
Denise Eady
20:38 24 Feb 20
I love this place. Best pharmacy around!!!. I have been using this pharmacy since it opened. Whenever I walk in,... everyone is very cordial and always pleasant and with a smile, and they always greet me by nmy name. Vic and the other Pharmacists are very knowledgeable, and the staff takes the time to explain any new medications in detail. If you are not able to pick up your prescriptions, they do HOME delivery which is great. I transferred from Walgreens pharmacy and I am so glad I did!!!read more
Jay Bhatt
Jay Bhatt
21:05 22 Feb 20
The quality of service provided by the pharmacist and the staff is excellent! I wouldn't go to any other pharmacy. They... truly care.read more
Cindy Hall
Cindy Hall
15:21 20 Feb 20
I never have to wait. This is the best pharmacy I ever went to. I highly recommend them to everyone!
Maisha Bryant
Maisha Bryant
00:32 20 Feb 20
I have known Vik and his family since they opened. They have bright back what it means to have a home town family... operated pharmacy. He remembers you, that you have had a baby etc. He is compassionate and always goes above and beyond. He trains his staff to pursue their own dreams. Some have gone on to school. My prayer is that God gives him a long healthy life and that his business continues to prosper. Oh and BTW if you move he does mail order so he can continue to be your pharmacist no need to switch!read more
Sharel E. Gordon-Love
Sharel E. Gordon-Love
19:46 19 Feb 20
My family has been with Drug Mart since they first open and we’ve received top notch service every single time. Vic... and the staff are very friendly, and we are greeted with a smileread more
Tammy Nichols
Tammy Nichols
23:23 18 Feb 20
I used to get my prescriptions at Cvs. But when Drug Mart open close to my house i figured I give then a try and have... not looked back. The staff is always kind, helpful, and considerate. LOVE THIS PLACE.❤read more
Yolanda Parker
Yolanda Parker
20:50 17 Feb 20
I enjoyed the customer service I experience when I go into this store the friendly atmosphere the warm welcome you get... upon entering and exitingread more
Mike Webb
Mike Webb
16:48 06 Feb 20
Great being able to pick up my meds at this pharmacy. They are the best!
Janet Bynum
Janet Bynum
18:21 28 Jan 20
Leaving his experience I had with Drug Mart it's coming there getting my medication and then delivering it to me very... happy who had Drug Mart in my life far as my medications is concerned I don't have to call for refills they deliver them to me I've been the drug mart play my medications concern about 7 years or more appreciate the people they appreciate me I'm happy with Drug Mart this is my the best pharmacist that I know thank youread more
james hunter
james hunter
21:25 24 Jan 20
Always ready to help! Any way possible thank you for all your years of service!
Michelle Reyes
Michelle Reyes
21:03 24 Jan 20
Awesome staff always willing to help out 🙂
cindy ortega
cindy ortega
20:41 24 Jan 20
I love this pharmacy. Everyone makes you feel like your family. Any issues with prescription they try to resolve it... asap. I recommend this pharmacy to everyone.read more
jacqueline wells
jacqueline wells
19:33 31 Dec 19
Drug mart has the most pleasant employees and the service is swift I can't say enough good things about this pharmacy... Thanks for your years of dedication and service in our communityread more
Chris Hanington
Chris Hanington
13:47 18 Jul 19
These people take great care of THEIR people. Impressive!
R Turner
R Turner
21:57 01 Jun 19
I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started... but their service is still top notch. Thanks again for all your help!read more
John Aleksandrowicz
John Aleksandrowicz
22:21 14 Apr 19
Great pharmacy with great customer service. Vik is great. He obviously cares about people and understands the needs of... each. Thank you!read more
Karen T
Karen T
18:54 06 Jan 19
This pharmacy is the best! I left Walgreens and very glad I did. They take the time to explain my medicines and know me... by name. I recommended them to all my family and friends.read more
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