NORVIR

ritonavir (RTV)

Used only as a booster for other drugs; recommended as a component of initial regimen in certain clinical situations

PKE drug

Booster

Norvir tablet

STANDARD DOSE

Used as a boosting agent for other protease inhibitors (increases the levels of other PIs), at smaller doses of 100 to 200 mg, taken either once or twice a day with the PI and a meal.

Take missed dose as soon as possible (at the same time as the other PI prescribed) unless it’s closer to the time of your next dose. Do not double up on your next dose. Do not crush or chew tablets or capsules; always swallow whole.

Approved for children older than one month with dosing based on body surface area; the use in children depends on the co-administered PI. Capsule formulation requires refrigeration, but tablet does not. Liquid formulation available (80 mg/mL) in peppermint and caramel flavor, but is not very palatable. The taste of the liquid can be improved by mixing with chocolate milk, peanut butter, Ensure, or Advera within one hour of dosing. Liquid formula should not be taken by pregnant women, as it contains 43% alcohol. Norvir oral powder available in 100 mg packets, is free of alcohol and propylene glycol (both of which are found in the liquid formula), and thus safer for pediatric use.

MANUFACTURER

Abbvie
norvir.com
(800) 633-9110

PHARMACY

Drug Mart Pharmacy
shopdrugmart.com
(800) 877-0337

GET STARTED – Request To Fill Your Medication

The side effect potential of Norvir is much lower now that it is only used as a booster at low doses. Most common side effects include stomach pain, nausea, diarrhea, and vomiting. Other less common side effects may include fatigue; tingling/numbness around the mouth, hands, or feet; loss of appetite; and taste disturbances. Norvir can also increase cholesterol and triglyceride levels. Measure liver function before starting and then monitor, with perhaps closer monitoring for those with underlying liver problems, especially during the first several months. No dose adjustment necessary with mild to moderate liver disease, but Norvir is not recommended for those with severe liver impairment.

Norvir interacts with many drugs. Do not take with alfuzosin, amiodarone, flecainide, lurasidone, propafenone, oral midazolam, triazolam, pimozide, ranolazine, Revatio, rifapentine, rifampin, voriconazole, ergot derivatives, or the herb St. John’s wort. Do not use lovastatin or simvastatin or co-formulations containing these drugs (Advicor and Vytorin) for the treatment of high cholesterol. Cholesterol-lowering alternatives are atorvastatin, rosuvastatin, pravastatin, pitavastatin, and fluvastatin, but should be used with caution and started at the lowest dose possible; monitor for increased side effects. Norvir increases levels of nasal and inhaled fluticasone (found in Advair, Flonase, Breo Ellipta, Arnuity Ellipta, and Flovent), which may lead to Cushing’s syndrome. Use an alternative corticosteroid and monitor for signs of Cushing’s syndrome (increased abdominal fat, fatty hump between the shoulders, rounded face, red/purple stretch marks, bone loss, possible high blood pressure, and sometimes diabetes). Trazodone concentrations may increase; a lower dose of trazodone is recommended. Norvir may decrease levels of methadone, therefore titrate dose of methadone to clinical effect. Use caution with anticonvulsants such as carbamazepine, phenobarbital, and phenytoin. Use calcium channel blockers (amlodipine, nifedipine, and others) with caution. Norvir may alter warfarin levels; additional monitoring is required. Norvir use with other blood thinners (anticoagulants), such as Xarelto, is not recommended. Norvir can increase anticoagulant concentrations (and thereby increase risk of bleeding) or decrease their concentrations (and thereby decrease effectiveness). Cialis, Levitra, and Viagra levels are increased; doses should not exceed 10 mg Cialis or 2.5 mg Levitra per 72 hours, or 25 mg Viagra per 48 hours. Monitor for increased side effects of these medications, such as visual disturbances, low blood pressure, dizziness, and prolonged painful erection lasting longer than 4 hours. Effectiveness of oral contraceptives may be decreased; consider using other or alternative methods of contraception. Levels of the street drug ecstasy are greatly increased by Norvir, and at least one death has been attributed to the combination. Using Norvir with methamphetamines can result in up to 2–3 fold increase in methamphetamine concentrations and puts user at risk for overdose. GHB, another street drug, is also dangerous with Norvir. Clarithromycin levels can increase by up to 80%. Co-administer bosentan, salmeterol, and immunosuppressants with caution. If co-administered, a lower dose of colchicine is recommended. Norvir, when combined with another PI, may be taken with Sovaldi, Daklinza (dose may need adjustment), Epclusa (monitor for tenofovir toxicity if TDF is part of regimen), and Harvoni (if TDF is not part of HIV regimen). Norvir + PI should not be taken with Olysio, Viekira Pak, or Zepatier. Tell your provider or pharmacist about all medications, herbals, and supplements you are taking or thinking of taking, prescribed or not, as there are other drug interactions which are not listed here.

The advantage of Norvir is its use with other PIs as a boosting agent (officially in the drug class called “pharmacokinetic enhancers”). As such, it’s used to increase the levels of some HIV protease inhibitor (PI) medications. An alternative to Norvir was approved in 2014 (see Tybost page). Stomach side effects are reduced by taking Norvir with high-fat foods—however, some other HIV medicines should not be taken with high-fat foods.

Once upon a time Norvir, or ritonavir, was approved as a treatment for HIV. It was one of the first PIs that slowed the death rates of HIV. For many, it was the rescuer from certain death. As with the other first generation PIs, it causes many debilitating side effects, including gastrointestinal problems and increased risk for liver toxicity. Because of the way it is metabolized, ritonavir increases the blood level of other drugs. It was hard to take because of its toxicities and drug interactions. Even though it failed as a treatment, it has proven to be, at a lower dose, an effective booster for newer and safer PIs.

Karen T.
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"They truly care, I tell everyone to go here. I've been with them since 2008."
Yolanda P.
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"Always helpful to save money on medication and very kind."
Michael A.
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"Helpful and knowledgeable. Can't ask for better service, thank you!"
Patti E.
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"The staff at Drug Mart are exceptionally helpful. The quality of their products are top notch. I recommend Drug Mart to everyone. Am with them for life!!"
Darryl F.
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"This is the best pharmacy I have ever been to. They are caring, helpful and treat you with respect."
Anita H.
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"My daughter was able to get emergency medication after hours within half hour of making the phone call to the 800#. I can't recommend Drug Mart more highly."
Robert T.
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"I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started but their service is still top notch. Thanks again for all your help!"
David D.
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"They are most accommodating, courteous, friendly and professional pharmacist I've ever dealt with. I'm so grateful to call this pharmacy my own."
Tonia B.
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"Always very caring when asking a question about your medication they know what they're talking about and they are very knowledgeable I've been going to them for oh my goodness since they opened up wow where did time go anyway my drug store for life thank you!"
Josh P.
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"This pharmacy is one of the best. Pharmacist has lots of knowledge and staff takes time to explain in detail. They do other half of what doctors should do. Also, no waiting like big name pharmacy. I highly recommend this pharmacy. They also deliver and ship to anywhere in USA."
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Drug Mart Pharmacy
5.0
Based on 163 reviews
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Chanice Dorsey
Chanice Dorsey
02:45 12 Mar 20
The staff at Drug Mart are truly an extension of my family. Vik offered me one of the greatest opportunities while in... nursing school, as a graduate, and as a working professional. He continues to encourage young adults to pursue their dreams and provides them with opportunities to be impactful within the community. You can’t get any better than this.read more
langston hannah
langston hannah
12:02 07 Mar 20
I am very pleased with the service that I receive from the pharmacy. The people who serve you are very helpful and... friendly and assist you in any way that they can. The pharmacist are well informed with your prescription needs, if there's a problem with anything you need they will do their best to resolve any issue you have. I recommend everyone to check them out and get their prescriptions filled at Drug Mart. I will always be a customer of Drug Mart because they are so good at what they do.read more
tracey evans
tracey evans
16:32 03 Mar 20
Drug Mart is my family, I’ve been with them since day 1. I moved away for a few years to another state, I’ve been... back i NJ. a little over 5 years and I’m still a happy customer. They’re very friendly, knowledgeable and very helpful and understanding, prices are better then most..read more
Cassandra Hemby
Cassandra Hemby
21:33 28 Feb 20
I so appreciate the dear people @Drug Mart! I am recovering from cancer and one day while in Chemotherapy I was told I... would need a certain cream right away, but I wouldn't be able to pick it up that day.however there is this very courteous and sweet young lady named Michele that assured me it would be delivered to me in at my daughter's home in Woodbridge, NJ, because that is where I go after having treatment.The kind of caring and compassion received there have made the staff endearing to me and has restored my faith in customer service again.read more
Denise Eady
Denise Eady
20:38 24 Feb 20
I love this place. Best pharmacy around!!!. I have been using this pharmacy since it opened. Whenever I walk in,... everyone is very cordial and always pleasant and with a smile, and they always greet me by nmy name. Vic and the other Pharmacists are very knowledgeable, and the staff takes the time to explain any new medications in detail. If you are not able to pick up your prescriptions, they do HOME delivery which is great. I transferred from Walgreens pharmacy and I am so glad I did!!!read more
Jay Bhatt
Jay Bhatt
21:05 22 Feb 20
The quality of service provided by the pharmacist and the staff is excellent! I wouldn't go to any other pharmacy. They... truly care.read more
Cindy Hall
Cindy Hall
15:21 20 Feb 20
I never have to wait. This is the best pharmacy I ever went to. I highly recommend them to everyone!
Maisha Bryant
Maisha Bryant
00:32 20 Feb 20
I have known Vik and his family since they opened. They have bright back what it means to have a home town family... operated pharmacy. He remembers you, that you have had a baby etc. He is compassionate and always goes above and beyond. He trains his staff to pursue their own dreams. Some have gone on to school. My prayer is that God gives him a long healthy life and that his business continues to prosper. Oh and BTW if you move he does mail order so he can continue to be your pharmacist no need to switch!read more
Sharel E. Gordon-Love
Sharel E. Gordon-Love
19:46 19 Feb 20
My family has been with Drug Mart since they first open and we’ve received top notch service every single time. Vic... and the staff are very friendly, and we are greeted with a smileread more
Tammy Nichols
Tammy Nichols
23:23 18 Feb 20
I used to get my prescriptions at Cvs. But when Drug Mart open close to my house i figured I give then a try and have... not looked back. The staff is always kind, helpful, and considerate. LOVE THIS PLACE.❤read more
Yolanda Parker
Yolanda Parker
20:50 17 Feb 20
I enjoyed the customer service I experience when I go into this store the friendly atmosphere the warm welcome you get... upon entering and exitingread more
Mike Webb
Mike Webb
16:48 06 Feb 20
Great being able to pick up my meds at this pharmacy. They are the best!
Janet Bynum
Janet Bynum
18:21 28 Jan 20
Leaving his experience I had with Drug Mart it's coming there getting my medication and then delivering it to me very... happy who had Drug Mart in my life far as my medications is concerned I don't have to call for refills they deliver them to me I've been the drug mart play my medications concern about 7 years or more appreciate the people they appreciate me I'm happy with Drug Mart this is my the best pharmacist that I know thank youread more
james hunter
james hunter
21:25 24 Jan 20
Always ready to help! Any way possible thank you for all your years of service!
Michelle Reyes
Michelle Reyes
21:03 24 Jan 20
Awesome staff always willing to help out 🙂
cindy ortega
cindy ortega
20:41 24 Jan 20
I love this pharmacy. Everyone makes you feel like your family. Any issues with prescription they try to resolve it... asap. I recommend this pharmacy to everyone.read more
jacqueline wells
jacqueline wells
19:33 31 Dec 19
Drug mart has the most pleasant employees and the service is swift I can't say enough good things about this pharmacy... Thanks for your years of dedication and service in our communityread more
Chris Hanington
Chris Hanington
13:47 18 Jul 19
These people take great care of THEIR people. Impressive!
R Turner
R Turner
21:57 01 Jun 19
I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started... but their service is still top notch. Thanks again for all your help!read more
John Aleksandrowicz
John Aleksandrowicz
22:21 14 Apr 19
Great pharmacy with great customer service. Vik is great. He obviously cares about people and understands the needs of... each. Thank you!read more
Karen T
Karen T
18:54 06 Jan 19
This pharmacy is the best! I left Walgreens and very glad I did. They take the time to explain my medicines and know me... by name. I recommended them to all my family and friends.read more
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