TYBOST

ritonavir (RTV)

Used only as a booster for other drugs; recommended as a component of initial regimen in certain clinical situations

PKE drug

Booster

Tybost tablet

STANDARD DOSE

150 mg once a day with food taken at the same time with either Prezista 800 mg (co-formulated as Prezcobix), Reyataz 300 mg (co-formulated as Evotaz), or co-formulated in the single-tablet regimens Stribild and Genvoya. For adults and children weighing at least 77 pounds (if taken with atazanavir, brand name Reyataz) or at least 88 pounds (if taken with darunavir, brand name Prezista).

Tybost is not an HIV drug; it is a pharmacokinetic enhancer or a “booster” used to increase the levels of Prezista 800 mg once daily, Reyataz 300 mg once daily, or elvitegravir 150 mg in Stribild and Genvoya. Tybost is not interchangeable with Norvir when used to increase the levels of other HIV medications.

Take missed dose as soon as possible (at the same time as any separate medication prescribed) unless it’s closer to the time of your next dose. Tybost is not recommended for people with CrCl less than 70 mL/min when co-administered with a regimen containing TDF or for people with severe liver problems.

MANUFACTURER

Gilead Sciences, Inc.
gilead.com
tybost.com
(800) GILEAD-5 (445–3235)

PHARMACY

Drug Mart Pharmacy
shopdrugmart.com
(800) 877-0337

GET STARTED – Request To Fill Your Medication

Side effects observed in clinical studies (greater than 2% of patients) include nausea, jaundice, and yellowing of the eyes. However, it was studied with Reyataz so the jaundice and yellowing of eyes were most likely due to the Reyataz component. Before taking Tybost, kidney function testing should be conducted, including serum creatinine, serum phosphorus, urine glucose, and urine protein. These measurements should continue to be monitored while taking Tybost. Cobicistat can cause a small, reversible increase in serum creatinine within the first few weeks of treatment without affecting actual kidney function. The SCr increase occurred within weeks of starting cobicistat and was reversible within a few days after stopping it. The co-adminstration of Tybost and Viread (tenofovir DF or TDF, also found in Complera, Stribild, and Truvada) is not recommended if the CrCl is less than 70 mL/min.

Tybost interacts with many drugs. Do not take with alfuzosin, colchicine, dihydroergotamine, dronedarone, ergotamine, irinotecan, simvastatin, lovastatin, lurasidone, methyl-ergonovine, ranolazine, rifampin, pimozide, triazolam, oral midazolam, Revatio, or St. John’s wort. Tybost may increase levels of nasal or inhaled fluticasone (Flonase, Advair, Breo Ellipta, Arnuity Ellipta, and Flovent). Use an alternative corticosteroid and monitor for signs of Cushing’s syndrome (increased abdominal fat, fatty hump between the shoulders, rounded face, red/purple stretch marks, bone loss, possible high blood pressure, and sometimes diabetes). No significant interactions with beclomethasone. Tybost may increase levels of certain calcium channel blockers, beta blockers, HMG-CoA reductase inhibitors (statins or cholesterol medicines), anticoagulants, antiplatelets, antiarrhythmics, antidepressants, sedative-hypnotics, rifabutin, bosentan, erectile dysfunction agents, inhaled corticosteroids, and norgestimate. Caution should be taken, with possible dose adjustments of these medications, when used with Tybost. Sporonox (antifungal) and Biaxin (antibiotic) may increase Tybost concentrations. Tybost may also increase Biaxin levels. Rifabutin and some anti-seizure medications, such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin) may decrease Tybost drug levels. Do not take with Olysio, Viekira Pak, or Zepatier. Avoid Harvoni if tenofovir disoproxil fumarate (TDF) is part of the HIV regimen. Tybost has similar drug interactions as Norvir, but they are not interchangeable and there may be some drug interactions with Tybost that are not observed with Norvir. Tybost may increase levels of methamphetamines. Tell your provider or pharmacist about all medications, herbals, and supplements you are taking or thinking of taking, prescribed or not, as there are other drug interactions which are not listed here.

Tybost is not an HIV medication. It is used to boost blood levels of Prezista and Reyataz and is available in fixed-dose tablets with those medications (see Evotaz and Prezcobix). Cobicistat is also part of the single-tablet regimens Genvoya and Stribild, both recommended therapies in the DHHS treatment guidelines in certain clinical situations. Tybost shares some of the same side effects of increased cholesterol and increased triglycerides as Norvir; however in clinical trials they were less pronounced. Tybost co-administered with darunavir or atazanavir should not be initiated in pregnant individuals and is not recommended during pregnancy. Inadequate levels of ART in second and third trimesters as well as viral breakthroughs have been reported. Tybost is not recommended during pregnancy. Tybost has not been studied separately from Genvoya, Stribild, Symtuza, Prezcobix, or Evotaz in individuals under 18 years of age; thus Tybost should not be used in pediatric patients.

Tybost, or cobicistat, is a drug developed to work as an enhancer to boost the level of other HIV drugs. Cobicistat is not an antiviral. This enhancer inhibits a liver enzyme used by many HIV drugs to be metabolized in the liver. Being a CYP3A4 inhibitor like ritonavir, it might cause the same side effects as ritonavir: increased triglycerides and cholesterol, as well as drug-drug interaction with many other drugs. One good thing about cobicistat is that it is less expensive and licensed for use in fixed-dose combinations.

Karen T.
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"They truly care, I tell everyone to go here. I've been with them since 2008."
Yolanda P.
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"Always helpful to save money on medication and very kind."
Michael A.
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"Helpful and knowledgeable. Can't ask for better service, thank you!"
Patti E.
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"The staff at Drug Mart are exceptionally helpful. The quality of their products are top notch. I recommend Drug Mart to everyone. Am with them for life!!"
Darryl F.
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"This is the best pharmacy I have ever been to. They are caring, helpful and treat you with respect."
Anita H.
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"My daughter was able to get emergency medication after hours within half hour of making the phone call to the 800#. I can't recommend Drug Mart more highly."
Robert T.
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"I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started but their service is still top notch. Thanks again for all your help!"
David D.
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"They are most accommodating, courteous, friendly and professional pharmacist I've ever dealt with. I'm so grateful to call this pharmacy my own."
Tonia B.
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"Always very caring when asking a question about your medication they know what they're talking about and they are very knowledgeable I've been going to them for oh my goodness since they opened up wow where did time go anyway my drug store for life thank you!"
Josh P.
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"This pharmacy is one of the best. Pharmacist has lots of knowledge and staff takes time to explain in detail. They do other half of what doctors should do. Also, no waiting like big name pharmacy. I highly recommend this pharmacy. They also deliver and ship to anywhere in USA."
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Drug Mart Pharmacy
5.0
Based on 163 reviews
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Chanice Dorsey
Chanice Dorsey
02:45 12 Mar 20
The staff at Drug Mart are truly an extension of my family. Vik offered me one of the greatest opportunities while in... nursing school, as a graduate, and as a working professional. He continues to encourage young adults to pursue their dreams and provides them with opportunities to be impactful within the community. You can’t get any better than this.read more
langston hannah
langston hannah
12:02 07 Mar 20
I am very pleased with the service that I receive from the pharmacy. The people who serve you are very helpful and... friendly and assist you in any way that they can. The pharmacist are well informed with your prescription needs, if there's a problem with anything you need they will do their best to resolve any issue you have. I recommend everyone to check them out and get their prescriptions filled at Drug Mart. I will always be a customer of Drug Mart because they are so good at what they do.read more
tracey evans
tracey evans
16:32 03 Mar 20
Drug Mart is my family, I’ve been with them since day 1. I moved away for a few years to another state, I’ve been... back i NJ. a little over 5 years and I’m still a happy customer. They’re very friendly, knowledgeable and very helpful and understanding, prices are better then most..read more
Cassandra Hemby
Cassandra Hemby
21:33 28 Feb 20
I so appreciate the dear people @Drug Mart! I am recovering from cancer and one day while in Chemotherapy I was told I... would need a certain cream right away, but I wouldn't be able to pick it up that day.however there is this very courteous and sweet young lady named Michele that assured me it would be delivered to me in at my daughter's home in Woodbridge, NJ, because that is where I go after having treatment.The kind of caring and compassion received there have made the staff endearing to me and has restored my faith in customer service again.read more
Denise Eady
Denise Eady
20:38 24 Feb 20
I love this place. Best pharmacy around!!!. I have been using this pharmacy since it opened. Whenever I walk in,... everyone is very cordial and always pleasant and with a smile, and they always greet me by nmy name. Vic and the other Pharmacists are very knowledgeable, and the staff takes the time to explain any new medications in detail. If you are not able to pick up your prescriptions, they do HOME delivery which is great. I transferred from Walgreens pharmacy and I am so glad I did!!!read more
Jay Bhatt
Jay Bhatt
21:05 22 Feb 20
The quality of service provided by the pharmacist and the staff is excellent! I wouldn't go to any other pharmacy. They... truly care.read more
Cindy Hall
Cindy Hall
15:21 20 Feb 20
I never have to wait. This is the best pharmacy I ever went to. I highly recommend them to everyone!
Maisha Bryant
Maisha Bryant
00:32 20 Feb 20
I have known Vik and his family since they opened. They have bright back what it means to have a home town family... operated pharmacy. He remembers you, that you have had a baby etc. He is compassionate and always goes above and beyond. He trains his staff to pursue their own dreams. Some have gone on to school. My prayer is that God gives him a long healthy life and that his business continues to prosper. Oh and BTW if you move he does mail order so he can continue to be your pharmacist no need to switch!read more
Sharel E. Gordon-Love
Sharel E. Gordon-Love
19:46 19 Feb 20
My family has been with Drug Mart since they first open and we’ve received top notch service every single time. Vic... and the staff are very friendly, and we are greeted with a smileread more
Tammy Nichols
Tammy Nichols
23:23 18 Feb 20
I used to get my prescriptions at Cvs. But when Drug Mart open close to my house i figured I give then a try and have... not looked back. The staff is always kind, helpful, and considerate. LOVE THIS PLACE.❤read more
Yolanda Parker
Yolanda Parker
20:50 17 Feb 20
I enjoyed the customer service I experience when I go into this store the friendly atmosphere the warm welcome you get... upon entering and exitingread more
Mike Webb
Mike Webb
16:48 06 Feb 20
Great being able to pick up my meds at this pharmacy. They are the best!
Janet Bynum
Janet Bynum
18:21 28 Jan 20
Leaving his experience I had with Drug Mart it's coming there getting my medication and then delivering it to me very... happy who had Drug Mart in my life far as my medications is concerned I don't have to call for refills they deliver them to me I've been the drug mart play my medications concern about 7 years or more appreciate the people they appreciate me I'm happy with Drug Mart this is my the best pharmacist that I know thank youread more
james hunter
james hunter
21:25 24 Jan 20
Always ready to help! Any way possible thank you for all your years of service!
Michelle Reyes
Michelle Reyes
21:03 24 Jan 20
Awesome staff always willing to help out 🙂
cindy ortega
cindy ortega
20:41 24 Jan 20
I love this pharmacy. Everyone makes you feel like your family. Any issues with prescription they try to resolve it... asap. I recommend this pharmacy to everyone.read more
jacqueline wells
jacqueline wells
19:33 31 Dec 19
Drug mart has the most pleasant employees and the service is swift I can't say enough good things about this pharmacy... Thanks for your years of dedication and service in our communityread more
Chris Hanington
Chris Hanington
13:47 18 Jul 19
These people take great care of THEIR people. Impressive!
R Turner
R Turner
21:57 01 Jun 19
I've been going here for years since my doctor recommended this pharmacy. They're busier now then when I first started... but their service is still top notch. Thanks again for all your help!read more
John Aleksandrowicz
John Aleksandrowicz
22:21 14 Apr 19
Great pharmacy with great customer service. Vik is great. He obviously cares about people and understands the needs of... each. Thank you!read more
Karen T
Karen T
18:54 06 Jan 19
This pharmacy is the best! I left Walgreens and very glad I did. They take the time to explain my medicines and know me... by name. I recommended them to all my family and friends.read more
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